New Atlas: Experimental enzyme inhibitor could herald new class of cancer drug
Pfizer is developing an oral drug to prevent COVID-19 infections. This drug, currently known as PF-07321332, is a protease inhibitor "designed to block the activity of the main protease enzyme that ...
ascopubs.org: Evaluation of MLN4924, an investigational NEDD8-activating enzyme (NAE) inhibitor, as a novel targeted agent with single-agent antitumor activity in mantle cell lymphoma (MCL ...
Evaluation of MLN4924, an investigational NEDD8-activating enzyme (NAE) inhibitor, as a novel targeted agent with single-agent antitumor activity in mantle cell lymphoma (MCL ...
(Philadelphia) -- Drugs that block the activity of an enzyme might hold a key to treating chronic and severe disorders such as certain forms of constipation, hemorrhoids, anal fissures, Hirschsprung's ...
MSN: SGLT2 inhibitors and IgAN: Can this diabetes drug delay kidney decline?
EurekAlert!: Consensus on the management of liver injury associated with targeted drugs and immune checkpoint inhibitors for hepatocellular carcinoma (version 2024)
Tyrosine kinase inhibitors (TKIs) are metabolized via the cytochrome P450 pathway, which may be associated with the production of toxic intermediates. These drugs can also induce oxidative stress and ...
Consensus on the management of liver injury associated with targeted drugs and immune checkpoint inhibitors for hepatocellular carcinoma (version 2024)
News Medical: New method to evaluate enzymes opens path to ferroptosis-targeting cancer drugs
New research could pave the way to develop cancer drugs targeting an enzyme that inhibits ferroptosis, a type of cell death. Cancer cells that are resistant to anticancer drugs are known to be ...