Hello I was recently diagnosed with an IgM kappa MGUS in August 2014 after a few months of fatigue and bone pain (43 year old ...
AL amyloid is more commonly associated with IgM-MGUS than other forms of MGUS. Thus, it is imperative that AL amyloid be carefully considered when evaluating patients with an IgM monoclonal protein." Reference:
Given your husband's history of anemia prior to his MGUS diagnosis, it seems reasonable for his doctors to believe it is due to something other than MGUS / myeloma. Given that he doesn't have any of the CRAB symptoms or other myeloma-defining events, his diagnosis is either MGUS or smoldering myeloma.
Re: MGUS diagnosis, but will I progress to multiple myeloma? by Mojbahar on Thu 10:14 pm Dear Trae,
New member here who was diagnosed with probable MGUS in April 2016. I say probable because my IgG kappa M-spike was low (0.5 g/dL, or ...
Unfortunately, just because your 24-urine test was negative, this doesn't put you in the clear for having a monoclonal gammopathy such as MGUS. All a negative 24-hour urine test result means is you are not producing enough monoclonal free light chains (which are different than the M-proteins measured in your blood) to show up in your urine.
CONCLUSIONS: Our findings, based on the largest number of autoimmune disorders and patients with MGUS/multiple myeloma reported to date, suggest that autoimmune diseases and/or their treatment may be important in the etiology of MGUS/multiple myeloma.
Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant plasma-cell disorder present in approximately 5% of the general population over the age of 50 years. MGUS is characterized ...