The word "on" fits better meaning "on the subject of question 1". The word "in" fits better meaning "occurring in question 1", or in its answer, if that is what is meant. The comments would be understood with either "on" or "in", though. Since you've invited rewording, these might work: For question 1, you repeated the example as a sentence.
I have a question on the grade you awarded me. I have a question on metaphysics. I'm having real trouble figuring out why on doesn't work in your example sentence. D (related) has a wider meaning: it indicates questions that have something to do with the course. In particular, related includes questions about the subject matter of the course.
When do I use is or does when I ask a question? For example, Is your item still for sale? Does your item still for sale? I am not sure which one to use.
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