IgM antibodies (immunoglobulins) are the first antibodies your immune system makes in response to an infection. High IgM might mean you’ve had a recent infection.
Immunoglobulin M: Your body makes IgM antibodies when you are first infected with new bacteria or other germs. They are your body's first line of defense against infections.
IgM binds to the polyimmunoglobulin receptor (pIgR) in a process that brings IgM to mucosal surfaces, such as the gut lumen and into breast milk. This binding depends on the J chain.
IgM is a type of antibody that binds to and neutralizes potentially harmful substances. Your immune system makes it as part of the initial response to things like germs.
Immunoglobulin M (IgM): What Do the Levels Mean and How to Get Tested
Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-immunoglobulins and have been highly conserved during evolution. IgMs are initially expressed during B cell ontogeny and are the first antibodies secreted following exposure ...
IgM is the third most abundant immunoglobulin in serum, with a concentration of 1.5 mg/ml. It is the largest antibody and is the first antibody to appear in response to the initial exposure to antigen.
IgM antibodies are the first immunoglobulins your body makes after you're exposed to a germ. They provide short-term protection while your body makes other antibodies.
IgM antibody acts by quickly recognizing and then initiating an immune response by directly neutralizing pathogens or clearing novel antigens. Besides mediating the response to immunological challenges, IgM antibody also participates in homeostatic functions of healthy tissue.