Nature: Iron deficiency in pregnant mice causes XY embryos to develop with female characteristics
In mice, a lack of maternal iron impairs an iron-dependent enzyme that activates the male sex-determining gene, causing some XY embryos to develop ovaries. The transition metals — including iron, ...
Iron deficiency in pregnant mice causes XY embryos to develop with female characteristics
The Scientist: Maternal Iron Deficiency Can Trigger Sex Reversal in Mouse Embryos
The team first created mice that lacked a key iron accumulation gene in the gonadal cells of XY embryos during the period of sex determination. These embryos had higher levels of DNA methylation, ...
MSN: Iron Deficiency Can Flip The Genetic Switch That Determines Sex, Turning Male Embryos into Female
A human’s sex is genetically determined. One of our 23 pairs of chromosomes carries genes that determine the embryo’s sex; males have two different sex chromosomes (XY) while females have two X ...
Iron Deficiency Can Flip The Genetic Switch That Determines Sex, Turning Male Embryos into Female
EurekAlert!: Maternal iron levels: An immense influence on sex determination in embryos
In mammals, the chromosomes that an individual is endowed with influence sex determination. This process occurs during embryonic development and relies on a balance between two very different sets of ...
A research team at Bar-Ilan University in Israel has reported that by making only slight changes to specific non-coding DNA regions in female mouse embryos, individuals with XX chromosomes, which are ...
IFLScience: Male Embryos Develop Ovaries In First-Ever Evidence Of Environment Affecting Mammalian Sex Determination
Male Embryos Develop Ovaries In First-Ever Evidence Of Environment Affecting Mammalian Sex Determination