Pyrexia of unknown origin (PUO) or fever of unknown origin (FUO) is frequently caused by common conditions that manifest atypically. There are various reasons that might cause fever, and they are categorised into infections, non-infectious inflammatory disorders, cancers, and other factors.
HIV-associated PUO, which includes patients who have HIV with fever as above for four weeks as outpatients or three days as inpatients, with an uncertain diagnosis after three days of investigation, where at least two days have been allowed for cultures to incubate.
For these reasons, it is important for physicians to approach PUO in a logical manner, and for the causes and approach to PUO to be continuously reviewed. In this article, we review the aetiology of PUO and the diagnostic strategies that may be used to investigate it.
The term PUO was first defined in 1961 by Petersdorf and Beeson. According to their classical definition, PUO is a fever higher than 38.3°C (101°F) on several occasions, lasting more than three weeks, and without a diagnosis after one week of hospital evaluation.
We retrospectively analyzed data of patients with PUO from a tertiary care hospital in Sri Lanka to determine the clinical course of PUO and the burden of the cost incurred in the treatment of PUO patients.
Pyrexia of unknown origin (PUO) and the cost of care in a tertiary care ...
Pyrexia of Unknown Origin (PUO) is a condition in which an individual has elevated body temperature, but despite investigations, no cause or explanation is found for this condition.
Pyrexia of Unknown Origin (PUO) | Treatment, Causes and Symptoms - skedoc