My mother is complaining of leg twitching at rest and early in the morning. She has PLS, in her legs and moving into her hands. She has shaky hands, and is dropping things, but really it’s the twitching in her legs that bothers her. She thinks it’s making them weaker, and she is having trouble...
PLS usually begins with lower-extremity stiffness and pain due to spasticity. With progression, which is a gradual process, people with PLS may develop balance problems and lower back and neck pain.
Just double-checking since bulbar-onset PLS is rare. You might consider work on how he will access his computer as he progresses, e.g. switches, a virtual keyboard, head mouse, etc. and explore apps where he could still create designs that someone else could form/fire.
PLS is generally given as a "probable" diagnosis because they give us four years to convert to ALS before giving it as a permanent diagnosis. Most convert to ALS and a small percentage will stay PLS.
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