Official answer: What is low dose naltrexone? Low dose naltrexone (LDN) means taking a dose of naltrexone that is up to one-tenth, or...
What is Low Dose Naltrexone (LDN)? LDN is a safe, non-toxic and inexpensive drug that helps regulate a dysfunctional immune system. It reduces pain, and fights inflammation. It is used to treat cancers, autoimmune diseases, chronic pain and mental health issues, to name a few.
Low-dose naltrexone has been shown to improve symptoms of fibromyalgia and chronic fatigue syndrome with minimal side effects. However, most of the LDN studies have been small, and more research on immune system and anti-inflammatory benefits is needed.
Low-dose naltrexone (LDN) refers to daily naltrexone dosages that are roughly one-tenth or less of the standard opioid addiction treatment dosage. Most published research suggests a daily dosage of 4.5 mg, but this can vary by a few milligrams. [1]
Low-dose naltrexone (LDN) has been demonstrated to reduce symptom severity in conditions such as fibromyalgia, Crohn’s disease, multiple sclerosis, and complex regional pain syndrome.
This review will discuss the pharmacology and current evidence for use of Low Dose Naltrexone (LDN) for treating chronic pain. Pharmacology: Mechanism of Action
Once LDN is metabolized by the liver and eliminated from the body (after 3-4 hours), the elevated levels of endorphins produced, as a result of the rebound effect, can now interact and bind with the more sensitive and more plentiful opioid receptors.
The serendipitous discovery of low-dose naltrexone (LDN) spurred a revolution in the background of medicine. Although still an experimental and unapproved approach, scientists are researching if LDN can help people with autoimmune diseases, chronic pain, inflammation, and fatigue.