It's also known as MOP3, and, less commonly, bHLHe5, BMAL, BMAL1C, JAP3, PASD3, and TIC. BMAL1 encodes a transcription factor with a basic helix-loop-helix (bHLH) and two PAS domains.
BMAL1 positively regulates myogenesis and negatively regulates adipogenesis via the transcriptional control of the genes of the canonical Wnt signaling pathway.
In this study, we developed a small molecule, Core Circadian Modulator (CCM), that targets the cavity in the PASB domain of BMAL1, causing it to expand, leading to conformational changes in the...
Overall, this work demonstrates that BMAL1 is a key metabolic sensor in macrophages, and its deficiency leads to a metabolic shift of enhanced glycolysis and mitochondrial respiration, leading to a heightened pro-inflammatory state.
The Circadian Clock Protein BMAL1 Acts as a Metabolic Sensor In ...
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly552 of human BMAL1 protein. Circadian rhythms govern many key physiological processes that fluctuate with a period of approximately 24 hours.
Loss of the circadian transcription factor BMAL1 in the paraventricular nucleus (PVN) of the hypothalamus reveals its importance in metabolic rhythms, but its functions in individual PVN cells are poorly understood.
Circadian rhythm dysfunction is a hallmark of Parkinson disease (PD), and diminished expression of the core clock gene Bmal1 has been described in patients with PD. BMAL1 is required for core circadian clock function but also serves nonrhythmic functions.
Bmal1 (Brain and muscle arnt-like), also known as Arntl, is a bHLH/PAS domain transcription factor that serves as a core factor in the transcription/translation feedback loop (TTFL) of the biological clock. Bmal1 forms a heterodimer with the protein product encoded by the Clock gene.